Kaletra (Lopinavir and Ritonavir)

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Kaletra $337.19
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Kaletra is a combination drug with two main components: lopinavir and ritonavir. Lopinavir, the first drug component, belongs to an inhibitor of the HIV-1 and HIV-2 proteases. Its main task is to provide antiviral activity of the drug.

Ritonavir is the second component of this drug. Its main function is to suppress HIV proteases. Both components are intended to make the virus entering the body inactive. It becmes impossible to bring damage to a human cell.

Indications

Treatment of HIV infection (part of combination therapy). It is applied in adults and children from 3 years old.

Dosage and administration

The recommended dose of Kaletra (film-coated tablets, 200/50 mg) is 400/100 mg (2 tablets) twice daily or 800/200 mg (4 tablets) once daily in patients with less than 3 mutations associated with the development of resistance to lopinavir/ritonavir. There is insufficient data for the use of this drug once a day in patients with 3 or more mutations associated with the development of resistance to lopinavir/ritonavir.

What are main contraindications of Kaletra (lopinavir/ritonavir)

  • Hypersensitivity to lopinavir, ritonavir or to additional drug components;
  • Severe liver failure;
  • Children’s age up to 3 years.

Before starting a coyrse of treatment, it is recommended consulting a healthcare professional. He/she will assess your health condtion and specify whether you have any contraindications to this drug application.

Possible side effects

When using generic Kaletra, side effects of the following character may occur:

  • nausea;
  • vomiting;
  • diarrhea;
  • increase in blood pressure;
  • atherosclerosis;
  • hepatitis;
  • stomatitis;
  • colitis;
  • pancreatitis;
  • migraine;
  • gastritis;
  • dizzine;
  • cramps;
  • tremors;
  • thrombosis;
  • alopecia;
  • vasculitis;
  • neuropathy;
  • lactic acidosis;
  • anxiety;
  • urticaria.

In some situations, there are disorders of the musculoskeletal mechanism in the form of osteonecrosis, myalgia, weakness in muscle structures.

Lactic acidosis, anemia cannot excluded; neutropenia, cellulitis; infection of the dermatological system; leukopenia, amenorrhea, furunculosis, menorrhagia, asthenia. Possible changes in some laboratory parameters.

In children, the medical personnel observe almost the same symptoms as in adults. Most often, children suffer from vomiting, diarrhea, skin rashes. Doctors describe individual cases of accidents that have occurred in some patients. These include myositis, myalgia, the development of autoimmune pathologies. Other possible side effects are an increase in body weight, which was associated with an increase in the volume of lipids in the human blood substance.

Possible interactions

Basically, this therapeutic agent (Generic Kaletra) is used in combination with other drugs. Only in this way, it is possible to achieve high results in treatment. In the case of the combined use of the compounds of zidovudine and abacavir, a decrease in the amount of the latter in the blood substance occurs. This feature should be considered by the doctor when prescribing a therapy regimen.

Can I get overdosed?

Currently, there is no information about the reaction of the human body to overdoses of Kaletra. No specific antidote has been developed. If the patient took an increased number of Kaletra tablets and found negative reactions, he/she is advised to urgently seek medical help at the hospital. Therapy should include supportive treatment. At the same time, vital indicators are strictly monitored. The medical staff will excrete substances that are not absorbed by stomach walls. Dialysis is not recommended, as it is ineffective.

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